Safety Profile Overview
Atypical antidepressant also approved for smoking cessation. Unique mechanism with lower sexual dysfunction rates versus SSRIs. Seizure risk at high doses.
Generic Name
bupropion
Brand Names
Wellbutrin, Zyban
Therapeutic Class
NDRI
Manufacturer
GSK
What Pharma Signal Tracks for Bupropion
- Adverse Events (FAERS) — All FDA Adverse Event Reporting System reports mentioning Bupropion, including serious outcomes, hospitalizations, and deaths.
- FDA Recalls — Class I, II, and III recalls, market withdrawals, and safety alerts related to Bupropion products.
- Label Changes — Boxed warning additions, new contraindications, dosing modifications, and safety-related labeling supplements.
- Risk Score — Composite risk score (0–100) combining adverse event rates, recall history, and label severity with explainable breakdown.
- Pharmacovigilance Signals — Proportional Reporting Ratio (PRR) and Reporting Odds Ratio (ROR) analysis detecting disproportionate adverse reactions.
- Trend Analysis — Monthly time series with anomaly detection for emerging safety signals.
Data Disclaimer: Pharma Signal aggregates data from the FDA Adverse Event Reporting System (FAERS) and other public regulatory sources. FAERS reports do not establish causation. Report counts may reflect prescription volume rather than relative safety. Always consult healthcare professionals for medical decisions.
Get Bupropion Safety Data via API
One API call returns adverse events, risk scores, recalls, and pharmacovigilance signals for Bupropion.
curl "https://api.pharma-signal.com/drug/safety/bupropion" \ -H "X-API-Key: your_key" # Returns risk score, adverse event counts, # serious/death rates, recalls, and signals
Related Safety Intelligence
Pharma Signal provides comparative analysis across therapeutic classes. Compare Bupropion against other NDRI drugs, or explore the full manufacturer portfolio for GSK.
- Head-to-head comparison — Compare up to 5 drugs side by side on all safety metrics.
- Therapeutic class benchmarking — See how Bupropion ranks within NDRI on serious event rates.
- Company portfolio risk — View all drugs from GSK with aggregate risk exposure.
- AI analyst briefs — Get a natural-language safety assessment combining all data sources.