Safety Profile Overview
Combination of naltrexone and bupropion for weight management. Boxed warning for suicidal thoughts from the bupropion component.
Generic Name
naltrexone/bupropion
Brand Names
Contrave
Therapeutic Class
Weight Management
Manufacturer
Nalpropion
What Pharma Signal Tracks for Contrave
- Adverse Events (FAERS) — All FDA Adverse Event Reporting System reports mentioning Contrave, including serious outcomes, hospitalizations, and deaths.
- FDA Recalls — Class I, II, and III recalls, market withdrawals, and safety alerts related to Contrave products.
- Label Changes — Boxed warning additions, new contraindications, dosing modifications, and safety-related labeling supplements.
- Risk Score — Composite risk score (0–100) combining adverse event rates, recall history, and label severity with explainable breakdown.
- Pharmacovigilance Signals — Proportional Reporting Ratio (PRR) and Reporting Odds Ratio (ROR) analysis detecting disproportionate adverse reactions.
- Trend Analysis — Monthly time series with anomaly detection for emerging safety signals.
Data Disclaimer: Pharma Signal aggregates data from the FDA Adverse Event Reporting System (FAERS) and other public regulatory sources. FAERS reports do not establish causation. Report counts may reflect prescription volume rather than relative safety. Always consult healthcare professionals for medical decisions.
Get Contrave Safety Data via API
One API call returns adverse events, risk scores, recalls, and pharmacovigilance signals for Contrave.
curl "https://api.pharma-signal.com/drug/safety/contrave" \ -H "X-API-Key: your_key" # Returns risk score, adverse event counts, # serious/death rates, recalls, and signals
Related Safety Intelligence
Pharma Signal provides comparative analysis across therapeutic classes. Compare Contrave against other Weight Management drugs, or explore the full manufacturer portfolio for Nalpropion.
- Head-to-head comparison — Compare up to 5 drugs side by side on all safety metrics.
- Therapeutic class benchmarking — See how Contrave ranks within Weight Management on serious event rates.
- Company portfolio risk — View all drugs from Nalpropion with aggregate risk exposure.
- AI analyst briefs — Get a natural-language safety assessment combining all data sources.